The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 02, 2002
Filed:
Nov. 12, 1999
Stanley B. Prusiner, San Francisco, CA (US);
Fred E. Cohen, San Francisco, CA (US);
Thomas L. James, Nicasio, CA (US);
Kiyotoshi Kaneko, Kodaira, JP;
The Regents of the University of California, Oakland, CA (US);
Abstract
Molecules are disclosed that interact with the cellular components involved in conversion of PrP to PrP . The molecules disclosed can be small molecules, peptides or protein analogs, e.g. analogs of PrP . In one embodiment, these molecules interfere with prion formation and/or replication, e.g. by preventing interactions of proteins involved in a prion complex or by interfering with &bgr;-sheet formation. In another embodiment, the molecules of the invention promote PrP conversion to PrP , e.g. by binding to PrP and facilitating a conformational change from PrP to PrP .