The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 19, 2002
Filed:
Nov. 22, 1999
Applicant:
Inventor:
David W. Rasnick, San Francisco, CA (US);
Assignee:
Enzyme Systems Products, Livermore, CA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 3/800 ; A61K 3/804 ; A01N 4/350 ; C07D / ; C07D / ;
U.S. Cl.
CPC ...
A61K 3/800 ; A61K 3/804 ; A01N 4/350 ; C07D / ; C07D / ;
Abstract
Novel &agr;-amino and peptidyl sulfonyl imidazolides, a method for their synthesis, and a method for inhibiting serine proteases therewith are disclosed. Pharmaceutical compositions containing &agr;-amino and peptidyl sulfonyl imidazolides and their use in the treatment of disease states characterized by an over-activity of serine proteases are also disclosed. Novel synthetic methods for the synthesis of sulfonyl derivatives, particularly &agr;-amino and peptidyl sulfonyl derivatives, from thioic acid S-esters are also disclosed.