The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 04, 2001
Filed:
Jan. 19, 1999
Applicant:
Inventors:
Robert Kovelman, La Jolla, CA (US);
Miguel Barbosa, San Diego, CA (US);
Assignee:
Signal Pharmaceuticals, Inc., San Diego, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 2/102 ;
U.S. Cl.
CPC ...
C07H 2/102 ;
Abstract
Reporter systems for assaying positive sense RNA virus replication are provided. The reporter systems comprise a reporter gene in antisense orientation, flanked by the complements of 5′ and 3′ viral genome ends, such that exposure to an RNA-dependent RNA polymerase results in the generation of mRNA encoding an active reporter protein. Such systems may be used, for example, to detect active RNA virus and to monitor RNA virus therapies.