The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 20, 2001
Filed:
Aug. 23, 2000
Dilip R. Wagle, Nanuet, NY (US);
Sheng-Ding Fang, Mahwah, NJ (US);
Taikyun Rho, Saddle Brook, NJ (US);
John J. Egan, Mountain Lakes, NJ (US);
Sara Vasan, Yonkers, NY (US);
Peter Ulrich, Old Tappan, NJ (US);
Anthony Cerami, New York, NY (US);
Alteon, Inc., Ramsey, NJ (US);
Abstract
The present invention relates to compositions and methods for reversing advanced glycosylation end product-mediated cross-linking and protein aging. Accordingly, compositions are described which comprise thiazolium compounds substituted with heterocyclic groups which are capable of reversing the formation of advanced glycosylation end product cross-links. Both industrial and therapeutic applications for the invention are disclosed, as food spoilage and animal protein aging can be treated. Such compounds have particular application in the treatment of protein aging such as is responsible for the complications of aging and diabetes.