The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 04, 2001
Filed:
Apr. 20, 1999
Sherie L. Morrison, Los Angeles, CA (US);
Koteswara R. Chintalacharuvu, Los Angeles, CA (US);
Esther Mikyung Yoo, Thousand Oaks, CA (US);
Kham M. Trinh, Monterey Park, CA (US);
M. Josefina Coloma, Santa Monica, CA (US);
The Regents of the University of California, Oakland, CA (US);
Abstract
Disclosed are modified immunoglobulin (Ig) molecules, a method of producing modified Ig molecules, and methods for treatment and prevention of infectious diseases using modified Ig molecules. In one embodiment, the modified Ig molecule comprises a C,3 domain of an IgA molecule (&agr; C,3). The combination of an &agr; C,3 with other domains selected from one or more nonIgA Ig molecules provides an Ig molecule that has the capacity to bind J chain and/or secretory component (SC) together with features of a nonIgA molecule. In another embodiment, the modified Ig molecule comprises a C,1 and/or a C,2 domain of an IgA molecule. The combination of an &agr; C,1 and/or C,2 domain with other domains selected from one or more nonIgA Ig molecules provides an Ig molecule that has the capacity to form higher polymers (trimers, tetramers, pentamers, etc.) together with features of a nonIgA molecule. In one embodiment, the modified immunoglobulin molecule lacks one or more carbohydrate addition sites.