The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 17, 2001
Filed:
Feb. 20, 1996
Applicant:
Inventors:
Carlos F. Barbas, San Diego, CA (US);
Dennis R. Burton, La Jolla, CA (US);
Richard A. Lerner, La Jolla, CA (US);
Assignee:
The Scripps Research Institute, La Jolla, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 3/940 ; A61K 3/942 ; C12Q 1/70 ; C12P 2/108 ; C07H 2/104 ;
U.S. Cl.
CPC ...
A61K 3/940 ; A61K 3/942 ; C12Q 1/70 ; C12P 2/108 ; C07H 2/104 ;
Abstract
The present invention describes synthetic human monoclonal antibodies that immunoreact with and neutralize human immunodeficiency virus (HIV). The synthetic monoclonal antibodies of this invention exhibit enhanced binding affinity and neutralization ability to gp120. Also disclosed are immunotherapeutic and diagnostic methods of using the monoclonal antibodies, as well as cell lines for producing the monoclonal antibodies.