The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 29, 2001
Filed:
Sep. 07, 1999
Applicant:
Inventors:
Simon Charles Dolan, Rickmansworth, GB;
Paolo Maragni, Virgilio, IT;
Alcide Perboni, S. Giorgio di Mautove, IT;
Assignee:
Glaxo Wellcome SpA, Verona, IT;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07F 9/50 ;
U.S. Cl.
CPC ...
C07F 9/50 ;
Abstract
A process for the preparation of the phosphonium compound of formula (1), which comprises reacting N-phenylpyrrolidinone (II), with pyridinium bromide perbromide, in the presence of a tertiary organic base and a suitable lewis acid and then treating the resultant bromo derivative (III) with the phosphine (IV, R,R,R,P) and the use of compound (I) when so prepared for the preparation of the glycine antagonist.