The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 29, 2001
Filed:
Jan. 31, 1991
Applicant:
Inventors:
Charles T. Esmon, Oklahoma City, OK (US);
Naomi L. Esmon, Oklahoma City, OK (US);
Deborah J. Stearns, Tokyo, JP;
Shinichiro Kurosawa, Tokyo, JP;
Assignee:
Oklahoma Medical Research Foundation, Oklahoma City, OK (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 1/4745 ; A61K 3/836 ; C12N 1/512 ;
U.S. Cl.
CPC ...
C07K 1/4745 ; A61K 3/836 ; C12N 1/512 ;
Abstract
Small, buffer soluble polypeptides having amino acid structures corresponding to residues 234-486, 310-486, and 407-486, of thrombomodulin and functionally equivalent analogs thereof inhibiting the clotting activity of thrombin and increasing protein C activation. The polypeptides can be coated onto the surface of articles adapted for contacting mammalian blood to render the surface non-thrombogenic. In pharmaceutical compositions, the polypeptides act as a natural anticoagulant.