The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 22, 2001
Filed:
May. 20, 1998
Robyn Joyce Russell, Wanniassa, AU;
Richard David Newcomb, Mt Albert, AU;
Peter Malcolm Campbell, Cook, AU;
Geoffrey Charles de Quetteville Robin, Aranda, AU;
Charles Claudianos, Isabella Plains, AU;
Kerrie-Ann Smyth, Syracuse, NY (US);
Thomas Mark Boyce, Syracuse, NY (US);
John Graham Oakeshott, Wanniassa, AU;
Jeremy Colin Brownlie, Via Queanbeyan, AU;
The Commonwealth Scientific and Industrial Research Organization, Australian Capital Territory, AU;
Abstract
The present invention provides an isolated DNA molecule encoding Malathion Carboxylesterase capable of hydrolysing at least one organophosphate selected from the group consisting of carboxylester organophosphates and dimethyloxon organophosphates. The DNA molecule comprises a nucleotide sequence having at least 60%, preferably at least 80% and more preferably at least 95% homology with Lc&agr;E,, in which the protein encoded by the DNA molecule differs from E,at least in the substitution of Trip at position,with an amino acid selected from the group consisting of Leu, Ser, Ala, Ile, Val, Thr, Cys, Met and Gly. The preferred substituents are Leu and Ser.