The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 27, 2001
Filed:
Aug. 06, 1998
Applicant:
Inventors:
Joël Crouzet, Sceaux, FR;
Francis Blanche, Paris, FR;
Michel Couder, Sucy en Brie, FR;
Béatrice Cameron, Paris, FR;
Assignee:
Aventis Pharma S.A., Antony, FR;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 3/851 ; C12N 9/12 ; C12N 1/500 ; C07H 2/104 ; C12Q 1/68 ;
U.S. Cl.
CPC ...
A61K 3/851 ; C12N 9/12 ; C12N 1/500 ; C07H 2/104 ; C12Q 1/68 ;
Abstract
The present invention relates to a nucleic acid sequence characterized in that it is derived from the wild nucleic acid sequence coding for a thymidine kinase, said nucleic acid sequence having at least one mutation in the region corresponding to the ATP binding site and conveniently a second mutation in the N-terminal region and/or C-terminal region. It also relates to variants of the wild thymidine kinase and their use in genic therapy.