The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 02, 2001
Filed:
Feb. 11, 1998
Frederick H. Hausheer, Boerne, TX (US);
Kochat Haridas, San Antonio, TX (US);
P. Seetharamulu, San Antonio, TX (US);
Dasharatha G. Reddy, San Antonio, TX (US);
Shijie Yao, San Antonio, TX (US);
Pavankumar N.V. Petluru, San Antonio, TX (US);
Dhanabalan Murali, San Antonio, TX (US);
BioNumerik Pharmaceuticals, Inc., San Antonio, TX (US);
Abstract
This invention relates to novel derivatives of camptothecin, and will, particularly to derivatives having a substitution at the C-7 position, or at one of the C-9, C-10, C-11 or C-12 positions, or to disubstituted derivatives having a first substitution at C-7 and a second at one of C-9, C-10, C-11 or C-12. The invention also includes methods of using the compounds as Topoisomerase I inhibitors to treat patients with cancer. The invention also includes pharmaceutical formulations which consist of the novel compounds in solution or suspension with one or more pharmaceutical excipients or dilutes.