The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 02, 2001
Filed:
May. 21, 1998
Randy J. Read, Edmonton, CA;
Penelope E. Stein, Cambridge, GB;
Stephen A. Cockle, Richmond Hill, CA;
Raymond P. Oomen, Tottenham, CA;
Sheena Loosmore, Aurora, CA;
Michel H. Klein, Willowdale, CA;
Glen D. Armstrong, Edmonton, CA;
Bart Hazes, Edmonton, CA;
Connaught Laboratories Limited, Toronto, CA;
Abstract
The three-dimensional structure of crystalline pertussis holotoxin (PT) has been determined by X-ray crystallography. Crystal structures have also been determined for complexes of pertussis toxin with molecules relevant to the biological activity of PT. These three-dimensional structures were analyzed to identify functional amino acids appropriate for modification to alter the biological properties of PT. Similar procedures may be used to predict amino acids which contribute to the toxicity of the holotoxin, to produce immunoprotective, genetically-detoxified analogs of pertussis toxin.