The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 19, 2000
Filed:
Jun. 17, 1997
Roland E Dolle, King of Prussia, PA (US);
Catherine P Prouty, Doylestown, PA (US);
Prasad V Chaturvedula, Cheshire, CT (US);
Stanley J Schmidt, Chester Springs, PA (US);
Vertex Pharmaceuticals Incorporated, Cambridge, MA (US);
Abstract
Disclosed are compounds, compositions and methods for inhibiting interleukin-1.beta. (IL-.beta.) protease activity. The compounds, N-(pyrimidinyl)-aspartic acid .alpha.-substituted methyl ketones and aspartic acid aldehydes, have the formula (I) set out herein. These compounds are inhibitors of 1.beta.-converting enzyme and as such are useful whenever such inhibition is desired. For example, they may be used as research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which 1L-.beta. protease activity is implicated.