The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 28, 2000
Filed:
Oct. 29, 1998
Jonathan T Skare, College Station, TX (US);
Ellen S Shang, Calabasas, CA (US);
Cheryl I Champion, Los Angeles, CA (US);
David R Blanco, Calabassas, CA (US);
James N Miller, Northridge, CA (US);
Michael A Lovett, Los Angeles, CA (US);
Tajib A Mirzabekov, Newton, MA (US);
Bruce L Kagan, Pacific Palisades, CA (US);
Paul Tempst, New York, NY (US);
Denise M Foley, Orange, CA (US);
The Regents of the University of California, Oakland, CA (US);
Abstract
The present invention presents three B. burgdorferi membrane proteins: Oms28, Oms45, and Oms66, each of about 28, 45, and 66 kDa respectively; and with average single channel conductances of about 0.6, 0.22, and 9.7 nS, respectively. Also disclosed are the methods for purifying these proteins from B. burgdorferi, methods for producing antibodies to these proteins, and the resulting antibodies. These proteins and their immunogenic fragments, and antibodies capable of binding to them are useful for inducing an immune response to pathogenic B. burgdorferi as well as providing a diagnostic target for Lyme disease. Further disclosed are the nucleotide and amino acid sequences, the cloning of the genes encoding the proteins and their recombinant proteins, and methods for obtaining the foregoing. Other B. burgdorferi outer membrane spanning proteins (Oms) obtainable by the isolation and purification methods of the present invention.