The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 07, 2000
Filed:
Dec. 14, 1998
Charles W Bishop, Madison, WI (US);
Ronald L Horst, Ames, IA (US);
Glenville Jones, Kingston, CA;
Nicholas J Koszewski, Lexington, KY (US);
Joyce C Knutson, Madison, WI (US);
Robert M Moriarty, Oak Park, IL (US);
Timothy A Reinhardt, Ames, IA (US);
Raju Penmasta, Westmount, IL (US);
Stephen Strugnell, Madison, WI (US);
Liang Guo, Bolingbrook, IL (US);
Sanjay K Singhal, Morton Grove, IL (US);
Lei Zhao, Lamont, IL (US);
Bone Care International, Inc., Madison, WI (US);
The United States of America as represented by the Secretary of, , US;
Abstract
1.alpha.,24(S)-Dihydroxy vitamin D.sub.2 which is useful as an active compound of pharmaceutical compositions for the treatment of disorders of calcium metabolism and for various skin disorders. The invention also includes preparation of synthetic 1.alpha.,24(S)-dihydroxy vitamin D.sub.2 starting from ergosterol which is converted in six steps to 24-hydroxyergosterol. 24-Hydroxyergosterol is irradiated and thermally converted to 24-hydroxy vitamin D.sub.2 which is converted in six steps to 1.alpha.,24(S)-dihydroxy vitamin D.sub.2. The syntheses also produced novel intermediates.