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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 6127598 B1

PDFFull Text
Date of Patent:
Oct. 03, 2000

Filed:

Jul. 25, 1997

Nkx-2.2 and nkx-6.1 transgenic mouse models for diabetes, depression,

Applicant:
Inventors:

Michael S German, San Francisco, CA (US);

John LR. Rubenstein, San Francisco, CA (US);

Lori Sussel, San Francisco, CA (US);

Maike Sander, San Francisco, CA (US);

Dennis J Hartigan-O'Connor, Ann Arbor, MI (US);

Roger A Pedersen, San Francisco, CA (US);

Juanito J Meneses, San Francisco, CA (US);

Assignee:

The Regents of the University of California, Oakland, CA (US);

Attorney:

Francis; Carol. L.

Primary Examiner:

Jasemine Chambers

Assistant Examiner:

Jill D Martin

Int. Cl.
CPC ...
C12N / ; C12N / ; C12N / ; C12N / ;
U.S. Cl.
CPC ...
800 18 ; 800-3 ; 800 13 ; 800-9 ; 800 21 ; 800 22 ; 800 25 ; 435-4 ; 435-6 ; 435 921 ; 435455 ; 435462 ; 435463 ; 424-921 ; 424 9321 ; 514 44 ;
Abstract

The present invention features mouse models for Nkx-2.2 gene function and for Nkx-6.1 gene function, wherein the transgenic mouse is characterized by having a defect in Nkx-2.2 gene function or a defect in Nkx-6.1 gene function (where, because Nkx-2.2 acts upstream of Nkx-6.1, a defect in Nkx-2.2 gene function affects Nkx-6.1 gene function) and by having a decreased number of insulin-producing cells relative to a normal mouse. Where the transgenic mouse contains a defect in Nkx-2.2 gene function, the mouse is further characterized by a decreased number of serotonin-producing cells relative to a normal mouse. The transgenic mice may be either homozygous or heterozygous for the Nkx-2.2 or Nkx-6.1 defect.

Find Patent Forward Citations

German, Michael. (2000). Nkx-2.2 and nkx-6.1 transgenic mouse models for diabetes, depression, (U.S. Patent No. 6127598). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/6127598

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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