The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 19, 2000
Filed:
Dec. 31, 1997
Alvin Peterson, Jamul, CA (US);
Lee K Landeen, San Diego, CA (US);
John Bennett, San Diego, CA (US);
Jason Gee, San Francisco, CA (US);
Scott Chesla, Atlanta, GA (US);
Joan Zeltinger, San Diego, CA (US);
James H Flatt, Del Mar, CA (US);
Mark A Applegate, San Diego, CA (US);
Noushin Dunkelman, San Diego, CA (US);
Stephen V Kemmerrer, San Diego, CA (US);
Advanced Tissue Sciences, Inc., La Jolla, CA (US);
Abstract
An apparatus and method for sterilizing, seeding, culturing, storing, shipping, and testing three-dimensional tissue constructs is disclosed. The apparatus includes a fluid reservoir, a pump, at least one treatment chamber, and a means for controlling media flow characteristics around a tissue construct disposed within the treatment chamber, and for controlling movement of the construct itself, so as to simulate a variety of physiologic conditions. One exemplary embodiment of the invention includes a means for applying an axial stress to the construct. Applying an axial stress to the construct during seeding and culturing results in a tissue-engineered construct with cells and their fibers oriented in a manner which is more likely to possess long term dimensional stability and the patency of native vessels with normal physiologic function.