The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 22, 2000
Filed:
Feb. 12, 1999
Shaukat Ali, Monmouth Junction, NJ (US);
J Craig Franklin, Skillman, NJ (US);
Imran Ahmad, Cranbury, NJ (US);
Eric Mayhew, Monmouth Junction, NJ (US);
Soumendu Bhattacharya, Plainsboro, NJ (US);
Gil Koehane, Piscataway, NJ (US);
Andrew S Janoff, Yardley, PA (US);
The Liposome Company, Inc., Princeton, NJ (US);
Abstract
Provided herein is a taxane having a hydrocarbon attached at the 2' and/or 7 positions, the hydrocarbon's alpha position being occupied by a 'hydrolysis-promoting group' ('HPG'). In one embodiment, the hydrolysis promoting group is stereospecifically attached to the .alpha.-carbon of the hydrophobic taxane. The Substitution of an HPG for the methylene unit ordinarily occupying the alpha position allows for enhanced in vivo hydrolysis of the hydrocarbon-taxane bond, and hence, for enhanced taxane therapeutic activity. Also provided herein are taxane-containing compositions, and methods of administering taxanes to animals, including those afflicted with cancers or inflammatory diseases.