The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 06, 2000
Filed:
May. 08, 1998
Linda Jolliffe, Belle Mead, NJ (US);
William Murray, Belle Mead, NJ (US);
Virginia Pulito, Flemington, NJ (US);
Allen Reitz, Lansdale, PA (US);
Xiaobing Li, San Diego, CA (US);
Linda Mulcahy, Flemington, NJ (US);
Cynthia Maryanoff, Forest Grove, PA (US);
Frank Villani, Perkasie, PA (US);
Ortho-McNeil Pharmaceutical, Inc., Raritan, NJ (US);
Abstract
This invention relates to a series of arylsubstituted piperazines, of Formula I ##STR1## pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the .alpha.-1a adrenergic receptor, a receptor which has been implicated in benign prostatic hyperplasia. As such the compounds are potentially useful in the treatment of this and other disease.