The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 16, 2000
Filed:
Oct. 22, 1998
Miguel Barbosa, San Diego, CA (US);
Graham K Bilter, San Diego, CA (US);
Robert Kovelman, La Jolla, CA (US);
Signal Pharmaceuticals, Inc., San Diego, CA (US);
Abstract
Plasmid reporter systems for assaying transcription and replication are provided. The plasmids comprise dual reporters for use in the independent evaluation of transcription and replication. Such plasmids may be used for example, for determining the role of endogenous factors in transcription and replication and for evaluating the effect of exogenous modulators on such processes. Within certain embodiments, the plasmids comprise (a) a first reporter gene operably linked to a promoter and a binding site for human papillomavirus E1 and/or E2 protein; (b) a second reporter gene that is linked to a promoter that is not substantially modulated by E1 and/or E2 and (c) an origin of replication bound by human papillomavirus E1 protein.