The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 02, 2000
Filed:
Dec. 04, 1998
Jean-Claude Aloup, Villeneuve-le-Roi, FR;
Francedilla.ois Audiau, Charenton-le-Pont, FR;
Michel Barreau, Montgeron, FR;
Dominique Damour, Orly, FR;
Arielle Genevois-Borella, Thiais, FR;
Jean-Claude Hardy, Cergy-Saint-Christophe, FR;
Patrick Jimonet, Villepreux, FR;
Franco Manfre, Limeil-Brevannes, FR;
Serge Mignani, Chatenay-Malabry, FR;
Patrick Nemecek, Thiais, FR;
Yves Ribeill, Villemoisson-sur-Orge, FR;
Rhone-Poulenc Rorer S.A., Antony, FR;
Abstract
A compound of formula (II): ##STR1## in which R is a hydrogen atom or a carboxy, alkoxycarbonyl, --CO--NR.sub.4 R.sub.5, --PO.sub.3 H.sub.2 or --CH.sub.2 OH radical, and R.sub.1 is an -alk-NH.sub.2, -alk-NH--CO--R.sub.3, -alk-COOR.sub.4, -alk-CO--NR.sub.5 R.sub.6 or --CO--NH--R.sub.7 radical. The compounds of formula (II) can be used to prepare compounds of formula (I): ##STR2## in which R and R.sub.1 have the same meanings as above. The compounds of formula (I) have valuable pharmacological properties and are antagonists of the .alpha.-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor, also known as the quisqualate receptor. The compounds of formula (I) are also non-competitive antagonists of the N-methyl-D-aspartate (NMDA) receptor and more specifically are ligands for NMDA receptor glycine modulator sites.