The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 23, 1999
Filed:
Dec. 15, 1998
Applicant:
Inventors:
Amy Arrow, Bethel, ME (US);
Roderic M Dale, Wilsonville, OR (US);
Tod Mitchell Woolf, Natick, MA (US);
Assignees:
Oligos Etc. Inc., Wilsonville, OR (US);
Other;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H / ; C12N / ; C12Q / ;
U.S. Cl.
CPC ...
435375 ; 435-6 ; 435 911 ; 536 231 ; 536 243 ; 536 2433 ; 536 245 ;
Abstract
This invention relates to antisense oligonucleotides that target mRNAs in cells as substrates for the cellular enzyme RNase H and thereby cause specific degradation of the targeted mRNA. The oligonucleotides have three components: a RNase H activating region, a complementarity region and 3' and 5' ends. The invention optimizes each of the components to resist intracellular nucleases, to increase hybridization to target mRNA, to specifically inactivate target mRNA in cells, and to decrease cytotoxicity.