The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 03, 1999
Filed:
Feb. 18, 1997
Irit Alkalay, Jerusalem, IL;
Yinon Ben-Neriah, Zion, IL;
Aaron Ciechanover, Haifa, IL;
Anthony Manning, San Diego, CA (US);
Frank Mercurio, San Diego, CA (US);
Avraham Yaron, Jerusalem, IL;
Signal Pharmaceuticals, Inc., San Diego, CA (US);
Yissum Research Development Company of the Hebrew University of Jerusalem, Jerusalem, IL;
Abstract
Compositions and methods for modulating the activation of nuclear factor .kappa.B (NF-.kappa.B) are provided. The compositions comprise one or more agents that modulate ubiquitination of phosphorylated I.kappa.B.alpha. and/or I.kappa.B.beta.. Such compositions may be used for treating diseases associated with NF-.kappa.B activation. Modulating agents include peptides that comprise a recognition domain for E3 ubiquitin ligase.