The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 08, 1999

Filed:

Aug. 19, 1997
Applicant:
Inventors:

Frederick H Hausheer, Boerne, TX (US);

Pavankumar NV. Petluru, San Antonio, TX (US);

Dasharatha Reddy, San Antonio, TX (US);

Dhanabalan Murali, San Antonio, TX (US);

Kochat Haridas, San Antonio, TX (US);

Peddaiahgari Seetharamulu, San Antonio, TX (US);

Shijie Yao, San Antonio, TX (US);

Assignee:

BioNumerik Pharmaceuticals, Inc., San Antonio, TX (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D / ;
U.S. Cl.
CPC ...
514 63 ; 514283 ; 546 14 ; 546 48 ; 544238 ;
Abstract

Novel compounds, formulations and methods of treating patients with cancer are provided for in this invention. The compounds are derivatives of camptothecin, and specifically relate to compounds having novel substitutions at the C-7 position of the camptothecin scaffold B-ring. The formula I compounds are highly lipophilic, lactone stable, do not require metabolic activation, and are potent antineoplastic compounds.


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