The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 11, 1999
Filed:
Apr. 11, 1997
Oded Gonen, Cheltenham, PA (US);
Gadi Goelman, Rosh Haaein, IL;
John S Leigh, Philadelphia, PA (US);
Lizann Bolinger, Philadelphia, PA (US);
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Abstract
Acquisition of three-dimensional image-guided localized proton spectroscopy (.sup.1 H-MRS) in the human brain is achieved on a standard clinical imager with a hybrid of chemical shift imaging (CSI) and transverse Hadamard spectroscopic imaging (HSI). 16.times.16.times.4 arrays of 3.5 and 1 ml voxels were obtained in 27 minutes. The spatially-selective HSI 90.degree. pulses were incorporated naturally into a PRESS double spin-echo sequence to subdivide the VOI into 4 partitions along its short axis. Two-dimensional CSI is performed along the other long axes. Because the hybrid excites the spins in the entire VOI, a .sqroot.N signal-to-noise-ratio (SNR) gain per given examination time is realized compared to sequentially interleaving N two-dimensional slices. A twofold gain in sensitivity is demonstrated in the brain for N=4.