The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 06, 1999

Filed:

Nov. 09, 1995
Applicant:
Inventors:

John P Cooke, Palo Alto, CA (US);

Victor J Dzau, Los Altos Hills, CA (US);

Gary H Gibbons, Palo Alto, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A23L / ; A61K / ; A61K / ;
U.S. Cl.
CPC ...
424439 ; 424441 ; 426648 ; 426656 ; 514564 ; 514565 ;
Abstract

Vascular function and structure is maintained or improved by long term administration of physiologically acceptable compounds, namely L-arginine, L-lysine, physiologically acceptable salts thereof, and polypeptide precursors thereof, which enhance the level of endogenous nitric oxide or other intermediates in the NO induced relaxation pathway in the host. In or in combination, other compounds, such as B.sub.6, folate, B.sub.12, or an antioxidant, which provide for short term enhancement of nitric oxide, either directly or by physiological processes may be employed.


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