The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 16, 1999

Filed:

Dec. 08, 1997
Applicant:
Inventors:

Roland Ellwood Dolle, III, King of Prussia, PA (US);

Hitesh K Patel, North Brunswick, NJ (US);

Theodore O Johnson, Jr, Plainsboro, NJ (US);

Carolyn DiIanni Carroll, Yardley, PA (US);

Shiwei Tao, Plainsboro, NJ (US);

Assignee:

Pharmacopeia, Inc., Princeton, NJ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D / ;
U.S. Cl.
CPC ...
548537 ; 544390 ; 544400 ; 546281 ; 548530 ; 564153 ;
Abstract

Compounds of Formula I ##STR1## are disclosed as inhibitors of plasmepsin and cathepsin D. The compounds are therefore useful to treat diseases such as malaria. In preferred compounds of formula I, Y is the residue of an N-acylated amino acid, a substituted 4-aminoproline or a substituted piperazinealkanoic acid. Intermediates in the solid phase synthesis of compounds of formula I, in which the compounds are attached to a solid support, are also disclosed.


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Dolle, III, Roland. (1999). Hydroxy-amino acid amides (U.S. Patent No. 5872262). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/5872262

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