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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 5739407 B1

PDFFull Text
Date of Patent:
Apr. 14, 1998

Filed:

Jun. 18, 1993

Human .beta.-casein, process for producing it and use thereof

Applicant:
Inventors:

Sven Bergstrom, Umea, SE;

Olle Hernell, Umea, SE;

Bo Lonnerdal, Davis, CA (US);

Karin Hjalmarsson, Umea, SE;

Lennart Hanson, Umea, SE;

Jan Tornell, Goteborg, SE;

Mats Stromqvigt, Umea, SE;

Assignee:

Symbicom aktiebolag, Umea, SE;

Attorney:

Cooper; Iver P.

Primary Examiner:

Bruce R Campell

Int. Cl.
CPC ...
C12N / ; C12N / ;
U.S. Cl.
CPC ...
800-2 ; 426580 ; 426590 ; 426648 ; 426657 ; 426801 ; 4351721 ; 4351723 ; 4353201 ; 530361 ; 536 235 ; 536 241 ; 800D / ; 935 60 ;
Abstract

The present invention relates to a DNA sequence encoding the human milk protein .beta.-casein or an analogue or variant thereof which has either the calcium binding activity of human .beta.-casein, or opioid activity, or angiotensin converting enzyme (ACE) inhibitory activity, or a combination of any two or three of these activities. The DNA sequence may optionally contain one or more intron sequences and permissive RNA splice signals. The DNA sequence is used in the production of recombinant human .beta.-casein, advantageously by means of production in transgenic non-human mammals such as bovine species. In one embodiment, the DNA sequence is inserted into a milk protein gene of a mammal such as a whey acidic protein (WAP) gene. The main use of the recombinant human .beta.-casein is as a constituent of infant formulae. It is contemplated that the recombinant human .beta.-casein provides a substantial improvement of the nutritional and biological value of the formulae in that a closer similarity to human milk is obtained.

Find Patent Forward Citations

Bergstrom, Sven. (1998). Human .beta.-casein, process for producing it and use thereof (U.S. Patent No. 5739407). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/5739407

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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