The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 07, 1998
Filed:
Jan. 19, 1995
Peter Robert Bernstein, Wallingford, PA (US);
Philip Duke Edwards, Kennet Square, PA (US);
Andrew Shaw, Kennett Square, PA (US);
Ashokkumar Bhikkappa Shenvi, Wilmington, DE (US);
Royston Martin Thomas, Macclesfield, GB;
Chris Allan Veale, Newark, DE (US);
Peter Warner, Macclesfield, GB;
Donald John Wolanin, Orange, CT (US);
Zeneca Limited, , GB;
Abstract
The present invention relates to certain novel substituted derivatives which are 1-pyrimidinylacetamide derivatives of formula I, ##STR1## which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these substituted derivatives, processes for preparing the substituted derivatives, pharmaceutical compositions containing such substituted derivatives and methods for their use.