The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 30, 1997
Filed:
May. 22, 1995
Stuart A Thompson, Joelton, TN (US);
Martin J Blaser, Nashville, TN (US);
Vanderbilt University, Nashville, TN (US);
Abstract
An isolated nucleic acid encoding the Helicobacter pylori recombinase is provided. Also provided is an isolated nucleic acid that hybridizes with the recombinase-encoding nucleic acid under stringent conditions and has at least 70% complementarity with the segment of the nucleic acid of SEQ ID NO:1 to which it hybridizes. Also provided is a mutant strain of H. pylori that does not express a functional recombinase (recA.sup.- mutant). An isolated nucleic acid encoding the Helicobacter pylori enolase is provided. Also provided is an isolated nucleic acid that hybridizes with the nucleic acid that encodes a H. pylori recombinase under stringent conditions and has at least 70% complementarity with the segment of the nucleic acid of SEQ ID NO:9 to which it hybridizes. Also provided is a mutant strain of H. pylori that does not express a functional enolase (eno.sup.- mutant). A method is provided for immunizing a subject against infection by H. pylori by administering to the subject an immunogenic amount of mutant H. pylori in a carrier for the mutant.