The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 09, 1997
Filed:
Jun. 05, 1995
Arthur Martin Felix, West Caldwell, NJ (US);
Edgar Philip Heimer, Nutley, NJ (US);
Roche Vitamins Inc., Paramus, NJ (US);
Abstract
Novel growth hormone releasing factor analogs are presented having the formula: ##STR1## wherein R.sub.1 is His, 3-MeHis, desNH.sub.2 His, Tyr, or desNH.sub.2 Tyr; R.sub.2 is Val, Leu, or Ile; R.sub.3 is Ala; R.sub.4 is Met, Leu, Ile, or Nle; R.sub.5 is Ser or Asn; R.sub.6 is an amino acid residue sequence selected from Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu or fragments thereof where the fragment is reduced in number by one to fifteen amino acid residues from the amino acid residue which carries the substituent X; and X is either OH or NH.sub.2, and the pharmaceutically acceptable acid or base addition salts thereof. The novel growth hormone releasing factor analogs demonstrate enhanced potency for the released growth hormone, have enhanced enzymatic stability, and can be administered to a subject having a deficiency of growth hormone or for improvement of growth performance in livestock.