The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 12, 1997
Filed:
Jan. 31, 1995
Applicant:
Inventors:
Nancy L Haigwood, Oakland, CA (US);
Guy Mullenbach, Oakland, CA (US);
Ernst-Guenter Afting, Marburg, DE;
Eric Paul Paques, Marburg, DE;
Assignees:
Chiron Corp., Emeryville, CA (US);
Behringwerke AG, Marburg-Lahn, DE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; C12N / ; C12N / ; C12N / ;
U.S. Cl.
CPC ...
424 9463 ; 435212 ; 435226 ; 4353201 ; 536 232 ;
Abstract
Novel polypeptide compositions based on the amino acid sequence of tissue plasminogen activator (tPA) are provided having improved properties over natural tissue plasminogen activator. Particularly, reduced fibrin stimulation of plasminogenolytic activity and/or enhanced affinity to fibrin surfaces are provided by modifying the C-terminus by deletions.