The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 15, 1997

Filed:

May. 25, 1995
Applicant:
Inventors:

John S Ng, Chicago, IL (US);

Claire A Przybyla, Sed Plaines, IL (US);

Richard A Mueller, Glencoe, IL (US);

Michael L Vazquez, Gurnee, IL (US);

Daniel P Getman, Chesterfield, MO (US);

John J Freskos, Clayton, MO (US);

Gary A DeCrescenzo, St. Peters, MO (US);

Deborah E Bertenshaw, Brentwood, MO (US);

Robert M Heintz, Ballwin, MO (US);

Suhong Zhang, Des Plaines, IL (US);

Chin Liu, Northbrook, IL (US);

Scott A Laneman, Vernon Hills, IL (US);

Assignee:

G.D. Searle & Co., Chicago, IL (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D / ;
U.S. Cl.
CPC ...
558345 ; 560 27 ; 560115 ; 560159 ; 556410 ; 556412 ;
Abstract

A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide or cyanohydrin from a chiral alpha amino aldehyde.


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