The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 15, 1997
Filed:
Nov. 30, 1994
Applicant:
Inventors:
Robert G Shorr, Edison, NJ (US);
Myung-Ok Cho, Highland Park, NJ (US);
Carl W Gilbert, Basking Ridge, NJ (US);
Edward J Ginns, Bethesda, MD (US);
Brian M Martin, Rockville, MD (US);
Assignee:
Enzon, Inc., Piscataway, NJ (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N / ; C12N / ; A61K / ;
U.S. Cl.
CPC ...
435188 ; 435209 ; 424 9461 ; 424 943 ;
Abstract
Conjugates containing glucocerebrosidase and non-antigenic polymers such as polyethylene glycol are disclosed. The conjugates circulate for extended times and have prolonged activity in vivo when compared to unmodified enzymes. The conjugates are useful in the treatment of Gaucher's Disease and have improved enzyme activity at the pH ranges associated with lysosomal, arterial and capillary regions.