The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 03, 1996
Filed:
Jun. 07, 1995
James D Ratajczyk, Waukegan, IL (US);
Juliette K Busse, Winthrop Harbor, IL (US);
Sanjay R Chemburkar, Gurnee, IL (US);
Daniel A Dickman, Grayslake, IL (US);
Yi-Yin Ku, Buffalo Grove, IL (US);
Hemantkumar H Patel, Waukegan, IL (US);
Ramesh R Patel, Chicago, IL (US);
David P Sawick, Wildwood, IL (US);
John N Starr, Grayslake, IL (US);
Bhadra Shelat, Lake Forest, IL (US);
Harry O Spiwek, Kenosha, WI (US);
Abbott Laboratories, Abbott Park, IL (US);
Abstract
A process for preparing a compound of the structure I ##STR1## where A is oxygen and sulfur and R.sup.1 is selected from the group consisting of hydrogen, halogen, alkyl of one to six carbon atoms, alkoxy of one to six carbon atoms, and trifluoromethyl, and R.sup.2 is alkyl of one to four carbon atoms, comprising coupling a compound of formula II: ##STR2## where X is bromine or iodine, with an N-hydroxyurea compound of formula III: ##STR3## in the presence of a palladium catalyst followed by reaction of the product thus formed with an alkali metal isocyante. The compounds of formula I are inhibitors of the enzyme 5-lipoxygenase and are thus useful as therapeutic agents for the treatment of allergic and inflammatory disease conditions.