The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 30, 1996
Filed:
Apr. 19, 1994
George H Searfoss, III, Birdsboro, PA (US);
Yuri D Ivashchenko, Audubon, PA (US);
Michael C Jaye, Glenside, PA (US);
Victoria J South, Audubon, PA (US);
Stephen M French, Phoenixville, PA (US);
Christopher Cheadle, West Chester, PA (US);
George A Ricca, Blue Bell, PA (US);
Rhone-Poulenc Rorer Pharmaceuticals Inc., Collegeville, PA (US);
Abstract
This invention provides a unique SH3 binding domain core motif of the sequence RPLPXXP and cDNA clones encoding proteins which interact with the SH3 domain of c-src, as well as the amino acid sequences which mediate this binding. Another embodiment of this invention is a method of identifying SH3-binding proteins and elucidating the sequences which mediate binding. This method may be used as an assay to select compounds which bind to this site and which inhibit or enhance the binding of the SH3 domain.