The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 02, 1996

Filed:

Oct. 25, 1994
Applicant:
Inventors:

James C Marsters, Jr, Oakland, CA (US);

Michael S Brown, Dallas, TX (US);

Craig W Crowley, Portola Valley, CA (US);

Joseph L Goldstein, Dallas, TX (US);

Guy L James, Dallas, TX (US);

Robert S McDowell, San Francisco, CA (US);

David Oare, Belmont, CA (US);

Thomas E Rawson, Mountain View, CA (US);

Mark Reynolds, So. San Francisco, CA (US);

Todd C Somers, Montara, CA (US);

Assignees:

Genentech, Inc., South San Francisco, CA (US);

Board of Regents, The University of Texas System, Austin, TX (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; C07D / ; C07D / ;
U.S. Cl.
CPC ...
540522 ; 540523 ; 540493 ; 540497 ; 540498 ; 540499 ; 540504 ; 540509 ; 540558 ;
Abstract

Benzodiazepine derivatives are disclosed that act as potent inhibitors of ras farnesyl:protein transferase. Pharmaceutical compositions containing these benzodiazepines are provided for treatment of diseases for which inhibition of the ras farnesyl:protein transferase is indicated. Also disclosed are benzazepines of the following general formula (II) having similar utility as the aforementioned benzodiazepines: ##STR1##


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