The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 14, 1996
Filed:
Jul. 08, 1992
Applicant:
Inventors:
Satoru Misawa, Toda, JP;
Hitoshi Matsuda, Toda, JP;
Yoshifumi Inoue, Toda, JP;
Hideyuki Furuya, Toda, JP;
Assignee:
Nippon Mining Company, Limited, Tokyo, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K / ; A61K / ; C12N / ; C12N / ;
U.S. Cl.
CPC ...
435 692 ; 435 691 ; 435 697 ; 43525233 ; 4353201 ; 530324 ; 536 234 ; 536 235 ; 514 12 ; 930250 ;
Abstract
Provided is a chimeric HV1/HV3 hirudin analog useful as an anti-coagulant, exhibiting higher anti-thrombin activity and less tendency to cause bleeding than hirudin HV1. Also provided are a method of producing hirudins and hirudin analogs, as well as other proteins, employing secretion vectors, and transformed microorganisms such as E. coli. Pharmaceutical compositions comprising various hirudins or the chimeric HV1/HV3 hirudin analog of the present invention and a pharmaceutically acceptable carrier are also disclosed.