The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 19, 1995
Filed:
May. 16, 1994
Applicant:
Inventors:
Akihiro Sakimae, Ohtake, JP;
Yuri Kagawa, Hiroshima, JP;
Ryozo Numazawa, Ohtake, JP;
Hisao Onishi, Hiroshima, JP;
Assignee:
Mitsubishi Rayon Company, Limited, Tokyo, JP;
Primary Examiner:
Int. Cl.
CPC ...
C12P / ;
U.S. Cl.
CPC ...
435280 ; 435131 ; 435170 ; 435822 ;
Abstract
N-(3-acetylthio-2-D-methylpropionyl)-L-proline useful as a precursor of captopril, one of antihypertensive agents, is prepared by allowing thioacetic acid to react with methyl methacrylate to prepare racetalc methyl 3-acetylthio-2-DL-methylpropionate, contacting the propionate with cells of, for example, Pseudomonas in order to effect biological and asymmetric hydrolysis, extracting 3-acetylthio-D-2-methylpropionic acid and allowing the acid to react with L-proline.