The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 19, 1995
Filed:
Oct. 19, 1992
Applicant:
Inventors:
Michael A Gimbrone, Jr, Jamaica Plain, MA (US);
Martin S Obin, Newton Centre, MA (US);
Joffre B Baker, El Granada, CA (US);
Caroline A Hebert, San Francisco, CA (US);
Assignees:
Brigham and Women's Hospital, Boston, MA (US);
Genentech, Inc., South San Francisco, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; A61K / ; A61K / ; C07K / ;
U.S. Cl.
CPC ...
424 852 ; 514886 ; 514-2 ; 514-8 ; 514 12 ; 530351 ;
Abstract
A novel polypeptide [Ala IL-8].sub.77 is provided which is a potent modulator of neutrophil functions. The polypeptide factor and related compositions find use as anti-inflammatory agents and as therapeutics for clinical indications in which damage to vascular endothelium and other tissues occurs. The amino acid and nucleotide sequence of the factor and methods for its purification, recombinant production and pharmaceutical use are provided.