The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 28, 1995
Filed:
Jun. 15, 1993
Applicant:
Inventors:
Jean Ackermann, Basel, CH;
David Banner, Basel, CH;
Klaus Gubernator, Freiburg, DE;
Paul Hadvary, Biel-Benken, CH;
Kurt Hilpert, Hofstetten, CH;
Klaus Muller, Munchenstein, CH;
Ludvik Labler, Bottmingen, CH;
Gerard Schmid, Kienberg, CH;
Thomas B Tschopp, Ettingen, CH;
Hans P Wessel, Heitersheim, DE;
Beat Wirz, Reinach, CH;
Assignee:
Hoffmann-La Roche Inc., Nutley, NJ (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; C07D / ; C07D / ; C07D / ;
U.S. Cl.
CPC ...
514323 ; 514183 ; 514211 ; 514212 ; 514220 ; 5142355 ; 514307 ; 514312 ; 514314 ; 514316 ; 514319 ; 514321 ; 514331 ; 514822 ; 540481 ; 540506 ; 540544 ; 540573 ; 540597 ; 544130 ; 544162 ; 544168 ;
Abstract
Compounds of the formula ##STR1## wherein L, M, R, T and X are set forth in the description, as well as hydrates or solvates thereof, which inhibit thrombin-induced platelet aggregation and clotting of fibrinogen in plasma, are described. The compounds of formula I are prepared by amidination or, depending on whether L is NH or O, by amide formation or esterification.