The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 01, 1994
Filed:
Sep. 26, 1991
Applicant:
Inventors:
Emil A Broger, Magden, CH;
Bernd Heiser, Inzlingen, DE;
Assignee:
Hoffman-LaRoche Inc., Nutley, NJ (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D / ; C07D / ;
U.S. Cl.
CPC ...
546146 ;
Abstract
A process for the preparation of isoquinoline derivatives of the formulas ##STR1## wherein R.sup.1 and R.sup.2 have the significances herein after set forth in the description, is described. The compounds of formula IV are obtained by asymmetrically hydrogenating the compounds of formula I. The compounds of formula I are, in turn, obtained by isomerizing compounds of the formulas ##STR2## or a mixture of compounds of the formulas ##STR3##