The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 31, 1994
Filed:
Sep. 06, 1991
Applicant:
Inventors:
Eugene C Butcher, Portola Valley, CA (US);
Louis J Picker, Dallas, TX (US);
Assignee:
Stanford University, Stanford, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N / ;
U.S. Cl.
CPC ...
435-724 ; 435-794 ; 435975 ; 436518 ; 436536 ; 436548 ;
Abstract
Methods and compositions are provided for determining neutrophil activation in a mammalian host by detecting the presence of shed LECAM-1 in the blood. By employing a monoclonal antibody which binds to a common epitope of lymphocyte and neutrophil LECAM-1 and a monoclonal antibody which binds to a sialylated Lewis X epitope which distinguishes between neutrophil and lymphocyte LECAM-1, the level of neutrophil activation can be determined. Various immunoassay protocols may be employed which detect the binding of the two antibodies to a common antigen.