The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 12, 1993
Filed:
Mar. 14, 1990
Applicant:
Inventors:
Keith M Gewain, Middelsex, NJ (US);
Douglas J MacNeil, Westfield, NJ (US);
Tanya MacNeil, Westfield, NJ (US);
Philip S Paress, Maplewood, NJ (US);
Carolyn L Ruby, Montclair, NJ (US);
Stanley L Streicher, Verona, NJ (US);
Assignee:
Merck & Co., Inc., Rahway, NJ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N / ; C12N / ; C12P / ;
U.S. Cl.
CPC ...
4351723 ; 435119 ; 43525233 ; 43525235 ; 4353201 ; 435 76 ; 935-9 ; 935 29 ; 935 72 ; 935 73 ; 935 75 ;
Abstract
There are disclosed plasmids containing DNA isolated from Streptomyces avermitilis, the microorganism which is used to prepare avermectin compounds, identified as pAT1, pVE650 pVE855, pVE859, pVE1446, pVE923, and pVE924 which contain the genetic information for the biosynthesis of the avermectins. Methods for the isolation of such plasmid and for the manipulation of the plasmids to alter the formation of the avermectin compound are also disclosed.