The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 31, 1993

Filed:

May. 23, 1989
Applicant:
Inventors:

Akira Arisawa, Yokohama, JP;

Naoto Kawamura, Yamato, JP;

Ikuo Kojima, Kawasaki, JP;

Yasushi Okumura, Oiso, JP;

Kazuhiko Okamura, Fujisawa, JP;

Hiroshi Tone, Yokohama, JP;

Rokuro Okamoto, Fujisawa, JP;

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N / ; C12N / ; C12N / ;
U.S. Cl.
CPC ...
43525233 ; 43525235 ; 4353201 ; 336 232 ; 935 11 ; 935 29 ; 935 73 ; 935 75 ;
Abstract

A DNA fragment containing acyB gene coding for an enzyme capable of acylating the 4'-position of a macrolide antibiotic, said DNA fragment being derived from a microorganism of the genus Streptomyces, having a size of about 3.1 kb and being characterized by the restriction endonuclease map shown in FIG. 1 , and a DNA restriction fragment resulting from digestion with a restriction endonuclease; a recombinant DNA plasmid containing this DNA fragment; a microorganism transformed with this recombinant plasmid; and a process for producing a 4'-acylated macrolide antibiotic by using the transformant.


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