logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 5229510 B1

PDFFull Text
Date of Patent:
Jul. 20, 1993

Filed:

Jan. 03, 1992

.beta.-lactams useful in determining the amount of elastase in a

Applicant:
Inventors:

Wilson B Knight, Watchung, NJ (US);

William K Hagmann, Westfield, NJ (US);

Alan L Maycock, Malvern, PA (US);

Assignee:

Merck & Co., Inc., Rahway, NJ (US);

Attorneys:

Panzer; Curtis C.

Speer; Raymond M.

Primary Examiner:

M L Berch

Int. Cl.
CPC ...
C07D / ; C07D / ; C07D / ; A61K / ;
U.S. Cl.
CPC ...
540360 ;
Abstract

Disclosed are .beta.-lactams of formula I ##STR1## wherein X is a chromogenic or fluorogenic substituted aryl or heteroaryl, which are specific inhibitors of Human leukocyte elastase (HLE). Upon contact with HLE these compounds are cleaved to form a chromogenic or fluorogenic species which may be readily measured by the assay disclosed herein. The assay thus provides a means for direct measurement of the amount of active HLE in a body fluid or other sample.

Find Patent Forward Citations

Knight, Wilson. (1993). .beta.-lactams useful in determining the amount of elastase in a (U.S. Patent No. 5229510). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/5229510

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

Loading…