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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 5215916 B1

PDFFull Text
Date of Patent:
Jun. 01, 1993

Filed:

Jun. 19, 1991

Super glucocorticoid receptors: receptors with increased affinity and

Applicant:
Inventors:

Samuel S Simons, Jr, Bethesda, MD (US);

Pradip K Chakraborti, Rockville, MD (US);

Keith R Yamamoto, San Francisco, CA (US);

Michael J Garabedian, San Francisco, CA (US);

Assignee:

The United States of America as represented by the Department of Health, , US;

Attorney:

Needle & Rosenberg

Primary Examiner:

Robert J Hill, Jr

Assistant Examiner:

John D Ulm

Int. Cl.
CPC ...
C07K / ; C12N / ; C12N / ;
U.S. Cl.
CPC ...
4352523 ; 435 691 ; 4353201 ; 530350 ; 536 235 ;
Abstract

The present invention relates to novel glucocorticoid receptors that have greater affinity and specifity for glucocorticoid steroids than the naturally occurring receptors. More particularly, the invention relates to the altering of the equivalent of cysteine-656 of the rat glucocorticoid receptor to either serine or glycine for the production of super glucocorticoid receptors which retain full biological activity in intact cells and have higher affinity and specificity for glucocorticoid steroid binding than the original receptor. The invention further relates to the recombinant expression of such altered receptors in host cells.

Find Patent Forward Citations

Simons, Jr, Samuel. (1993). Super glucocorticoid receptors: receptors with increased affinity and (U.S. Patent No. 5215916). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/5215916

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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