The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 29, 1992
Filed:
Jan. 14, 1991
Applicant:
Inventors:
Sudhakar Kasina, Kirkland, WA (US);
Ananthachari Srinivasan, Kirkland, WA (US);
John M Reno, Brier, WA (US);
Linda M Gustavson, Seattle, WA (US);
Jeffrey N Fitzner, Seattle, WA (US);
David S Jones, San Diego, CA (US);
Assignee:
NeoRx Corporation, Seattle, WA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K / ; C07K / ; A61K / ;
U.S. Cl.
CPC ...
5303915 ; 530331 ; 5303913 ; 530395 ; 530351 ; 530408 ; 530409 ; 424-11 ; 534 10 ; 536-41 ; 549419 ; 549496 ; 548548 ; 548517 ; 2609982 ; 558 17 ; 558254 ; 560110 ; 560251 ;
Abstract
Chelating compounds of specified N.sub.2 S.sub.2 N.sub.3 S derived structure are useful for radiolabeling targeting molecules such as antibodies. Cleavable ester orthioester linkers connect the radionuclide metal chelates to the antibodies. The radiolabeled antibodies have improved biodistribution properties, including reduced localization within the intestines and kidneys.