The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 12, 1992
Filed:
Dec. 29, 1989
Applicant:
Inventors:
Linda M Gustavson, Seattle, WA (US);
Ananthachari Srinivasan, Kirkland, WA (US);
Sudhakar Kasina, Kirkland, WA (US);
John M Reno, Brier, WA (US);
Jeffrey N Fitzner, Seattle, WA (US);
David S Jones, Seattle, WA (US);
Assignee:
NeoRx Corporation, Seattle, WA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K / ; C07K / ; A16K / ; A16K / ;
U.S. Cl.
CPC ...
5303915 ; 530317 ; 530331 ; 5303911 ; 530351 ; 530395 ; 530408 ; 530409 ; 435188 ; 435217 ; 424-11 ; 424-9 ; 424 8591 ; 424 851 ; 424 943 ; 534 10 ; 534 14 ; 514-8 ; 514 12 ; 514 21 ; 549496 ; 549419 ; 548548 ; 548517 ; 558254 ; 560110 ; 560251 ;
Abstract
Chelating compounds of specified structure are useful for radiolabeling targeting molecules such as antibodies. Cleavable linkers connect the radionuclide metal chelates to the antibodies. The radiolabeled antibodies have improved biodistribution properties, including reduced localization within the intestines and kidneys.