The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 06, 1991
Filed:
Apr. 03, 1989
Applicant:
Inventors:
Leslie D Bell, Chesterfield, MO (US);
Ernest J Mayer, King of Prussia, PA (US);
Mark O Palmier, Webster Groves, MO (US);
H Eser Tolunay, Creve Coeur, MO (US);
Thomas G Warren, Ballwin, MO (US);
Tze-Chein Wun, St. Louis, MO (US);
Assignee:
Monsanto Company, St. Louis, MO (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N / ; C12N / ; C12P / ; A61K / ;
U.S. Cl.
CPC ...
435226 ; 435219 ; 4353201 ; 4352402 ; 536 27 ; 935 14 ; 935 70 ; 935 23 ; 935 27 ; 424 9464 ;
Abstract
A modified tissue plasminogen activator having an improved in vivo half-life characterized in that the normal protein moiety of 527 amino acids is mutated at the site Cys73.fwdarw.Arg and at the site Lys277.fwdarw.Asp.